How to block skype in from cisco routers ..................................??????/

NBAR configuration to drop Skype packets

class−map match−any p2p
match protocol skype

policy−map block−p2p
class p2p
drop
int FastEthernet0
description PIX−facing interface
service−policy input block−p2p

If you are unsure about the bandwidth eating applications being used in your organisation. you can access the interface connected to the Internet and configure following command

ip nbar protocol-discovery.

This will enable nbar discovery on your router.

Use following command:- 

show ip nbar protocol-discovery stats bit-rate top-n 10

it will show you top 10 bandwidth eating applications being used by the users. Now you will be able to block/restrict traffic with appropriate QoS policy.

we can also use ip nbar port-map command to look for the protocol or protocol name, using a port number or numbers other than the well-known Internet Assigned Numbers Authority (IANA)-assigned) port numbers.

Usage as per cisco:-
ip nbar port-map protocol-name [tcp | udp] port-number

Up to 16 ports can be specified with this command. Port number values can range from 0 to 65535.

Thanks .